| Kolo | Datum | Domaćin | Gost | Rez | Zap | |
|---|---|---|---|---|---|---|
| 1. | 12.08.18. | Southampton | - | Burnley | 0 : 0 | |
| 2. | 18.08.18. | Everton | - | Southampton | 2 : 1 | |
| 3. | 25.08.18. | Southampton | - | Leicester City | 1 : 2 | |
| 4. | 01.09.18. | Crystal Palace | - | Southampton | 0 : 2 | |
| 5. | 17.09.18. | Southampton | - | Brighton & Hove Albion | 2 : 2 | |
| 6. | 22.09.18. | Liverpool | - | Southampton | 3 : 0 | |
| 7. | 29.09.18. | Wolverhampton | - | Southampton | 2 : 0 | |
| 8. | 07.10.18. | Southampton | - | Chelsea | 0 : 3 | |
| 9. | 20.10.18. | Bournemouth | - | Southampton | 0 : 0 | |
| 10. | 27.10.18. | Southampton | - | Newcastle | 0 : 0 | |
| 11. | 04.11.18. | Manchester City | - | Southampton | 6 : 1 | |
| 12. | 10.11.18. | Southampton | - | Watford | 1 : 1 | |
| 13. | 24.11.18. | Fulham | - | Southampton | 3 : 2 | |
| 14. | 01.12.18. | Southampton | - | Manchester United | 2 : 2 | |
| 15. | 05.12.18. | Tottenham | - | Southampton | 3 : 1 | |
| 16. | 08.12.18. | Cardiff City | - | Southampton | 1 : 0 | |
| 17. | 16.12.18. | Southampton | - | Arsenal | 3 : 2 | |
| 18. | 22.12.18. | Huddersfield Town | - | Southampton | 1 : 3 | |
| 19. | 27.12.18. | Southampton | - | West Ham | 1 : 2 | |
| 20. | 30.12.18. | Southampton | - | Manchester City | 1 : 3 | |
| 21. | 02.01.19. | Chelsea | - | Southampton | 0 : 0 | |
| 22. | 12.01.19. | Leicester City | - | Southampton | 1 : 2 | |
| 23. | 19.01.19. | Southampton | - | Everton | 2 : 1 | |
| 24. | 30.01.19. | Southampton | - | Crystal Palace | - : - | |
| 25. | 02.02.19. | Burnley | - | Southampton | - : - | |
| 26. | 09.02.19. | Southampton | - | Cardiff City | - : - | |
| 27. | 23.02.19. | Arsenal | - | Southampton | - : - | |
| 28. | 26.02.19. | Southampton | - | Fulham | - : - | |
| 29. | 02.03.19. | Manchester United | - | Southampton | - : - | |
| 30. | 09.03.19. | Southampton | - | Tottenham | - : - | |
| 31. | 16.03.19. | Watford | - | Southampton | - : - | |
| 32. | 30.03.19. | Brighton & Hove Albion | - | Southampton | - : - | |
| 33. | 06.04.19. | Southampton | - | Liverpool | - : - | |
| 34. | 13.04.19. | Southampton | - | Wolverhampton | - : - | |
| 35. | 20.04.19. | Newcastle | - | Southampton | - : - | |
| 36. | 27.04.19. | Southampton | - | Bournemouth | - : - | |
| 37. | 04.05.19. | West Ham | - | Southampton | - : - | |
| 38. | 12.05.19. | Southampton | - | Huddersfield Town | - : - |